Lyrica product description
An active ingredient in Lyrica is pregabalin, which has an anticonvulsant and antiepileptic effect. Corporation Pfizer synthesized pregabalin at the end of the last century. The company originally placed pregabalin as a modern antiepileptic drug, without the serious side effects that are typical of this class of drugs and do not cause addiction. Later, it turned out that Lyrica remarkably fights anxiety and relieves depression, and the scope has naturally expanded.
mechanism of action of pregabalin has not yet been fully studied. It is known that the substance acts on the same areas of the brain as sedatives, but it is not clear why it causes the physical and mental tension that is not specific to sedatives. In medical circles, pregabalin has established itself as a drug for the treatment of epilepsy and anxiety.
During Lyrica treatment, it is necessary to avoid driving vehicles and engaging in potentially dangerous activities that require a high concentration of attention and speed of psychomotor reactions.
Women of reproductive age should use reliable contraception while taking pregabalin. The drug is prescribed to pregnant women only if the intended benefit to the mother outweighs the risk to the fetus.
If patients with diabetes mellitus on the background of taking Lyrica increased body weight, correction of doses of hypoglycaemic drugs is necessary. Treatment of the elderly can cause dizziness and drowsiness, which increases the risk of injury in the latter.
Do not administer Lyrica to patients with hypersensitivity to pregabalinum or other components of the drug. It is contraindicated in children under 17 years of age, women breast-feeding and people with impaired lactose absorption and lactose intolerance.
Interaction with other subjects
Pregabalin is metabolised to an insignificant extent in the body and does not bind to plasma proteins, so the pharmacokinetic interaction between Lyric and other medicinal products is unlikely.
Intaget av Lyrica kan öka effekterna av Lorazepam och etanol. Med samtidig användning av pregabalin och oxykodon är det en ökning av försämringar av den mnestiska funktionen och de grundläggande motorfunktionerna, som orsakas av intaget av oxykodon.
Läkemedlet påverkar inte de farmakologiska effekterna av andra antikonvulsiva medel, liksom effekten av orala preventivmedel, diuretika, orala antidiabetika och insulin.
In evidence-based medicine, there is no evidence of a negative effect of Lyrica on the liver. In fact, pregabalin is not processed in the liver, therefore its toxic effect on this organ is minimal. Regarding the influence of pregabalin on sexual function – there is no reliable information on the irreversible damage to the testicles and the impotence caused by Lyrica. But the negative impact of Lyrica on the kidneys causes no doubt.
Many patients complain of swollen limbs and low back pain during treatment with pregabalin. In addition, according to a recent experiment with mice, pregabalin and its precursors may interfere with the development of cell bonds in the brain, which is too full of early dementia.